慢性呼吸道感染常见病原菌耐药性、致病性、免疫逃逸机制相关研究，群体感应系统，病原菌种内/间互作及新型小分子抗菌药物的开发及应用。

1.Kelei Zhao, Wujiao Li, Jing Li, Teng Ma, Kailun Wang, Yang Yuan, Jing Shirley Li, Rou Xie, Ting Huang, Yige Zhang, Yingshun Zhou, Nongyu Huang, Wenling Wu, Zhen Wang, Jun Zhang, Bisong Yue, Zongguang Zhou, Jiong Li, Yuquan Wei, Xiuyue Zhang*, Xikun Zhou*. TesG is a type I secretion effector of Pseudomonas aeruginosa that suppresses the host immune response during chronic infection. Nature Microbiology, 2019, 4: 459–469. (Highlighted)
2.Xinyu Jia, Zhiling Pan1, Yang Yuan2, Bingnan Luo, Yongbo Luo, Sunandan Mukherjee, Guowen Jia, Liu Liu, Xiaobin Ling, Xiting Yang, Zhichao Miao, Xiawei Wei, Janusz M. Bujnicki, Kelei Zhao*, Zhaoming Su*. Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence. Cell Research, 2023. Accepted on 2023. 01. 31.
3.Lianming Dua, Chaoyue Geng, Qianglin Zeng, Ting Huang, Jie Tang, Yiwen Chu, Kelei Zhao*. Dockey: a modern integrated tool for large-scale molecular docking and virtual screening. Briefings in Bioinformatics. 2023. Accepted on 2023. 01. 23.
4.Lianming Du, Qin Liu, Zhenxin Fan, Jie Tang, Xiuyue Zhang, Megan Price, Bisong Yue*, Kelei Zhao*. Pyfastx: a robust Python package for fast random access to sequences from plain and gzipped FASTA/Q files. Briefings in Bioinformatics. 2021. 22(4): bbaa368. doi: 10.1093/bib/bbaa368. IF 13.994.
5.Kelei Zhao, Linjie Liu, Xiaojie Chen*, Ting Huang, Lianming Du, Jiafu Lin, Yang Yuan, Yingshun Zhou, Bisong Yue, Kun Wei, Yiwen Chu*. Behavioral heterogeneity in quorum-sensing can stabilize social cooperation in microbial populations. BMC Biology, 2019, 17: 20.
6.Jing Li, Xiaojie Chen*, Jiafu Lin, Yang Yuan, Ting Huang, Lianming Du, Balakrishnan Prithiviraj, Aixue Zhang, Xinrong Wang, Yiwen Chu, Kelei Zhao*. Antibiotic intervention redisposes bacterial interspecific interacting dynamics in competitive environments. Environmental Microbiology. 2021. 23:7432-7444.
7.Kelei Zhao, Jing Li, Xiting Yang, Qianglin Zeng, Wei Liu, Yi Wu, Hui Zhou, Balakrishnan Prithiviraj, Xinrong Wang, Xikun Zhou*, Yiwen Chu*. Subinhibitory cefotaxime and levofloxacin contribute to selecting Pseudomonas aeruginosa from the coculture with Staphylococcus aureus. Applied and Environmental Microbiology. 2022. 88(12):e0059222.
8.Qianglin Zeng, Xiting Yang, Heyue Li, Jiajie Zhang, Yamei Zhang, Hui Zhou, Kelei Zhao*. Identification of a multidrug resistant Pseudomonas aeruginosa isolate harboring infrequent red fluorescence plasmid from COPD Patient. Infection and Drug Resistance. 2022. 15:7301–7305.
9.Yang Yuan, Xiting Yang, Qianglin Zeng, Heyue Li, Ruyi Fu, Lianming Du, Wei Liu, Yamei Zhang, Xikun Zhou, Yiwen Chu, Xiuyue Zhang*, Kelei Zhao*. Repurposing Dimetridazole and Ribavirin to disarm Pseudomonas aeruginosa virulence by targeting the quorum sensing system. Frontiers in Microbiology. 2022. 13:978502.
10.Qin Chen, Kelei Zhao*, Heyue Li, Kanghua Liu, Jing Li, Yiwen Chu, Balakrishnan Prithiviraj, Bisong Yue, Xiuyue Zhang*. Antibacterial and anti-virulence effects of furazolidone on Trueperella pyogenes and Pseudomonas aeruginosa. BMC Veterinary Research. 2022. 18:114.
11.Kelei Zhao*, Ting Huang, Jiafu Lin, Chaochao Yan, Lianming Du, Tao Song, Jing Li, Yidong Guo, Yiwen Chu, Junfeng Deng, Xinrong Wang, Chaolan Liu, Yingshun Zhou*. Genetic and functional diversity of Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease. Frontiers in Microbiology, 2020, 11:598478.
12.Yang Yuan, Jing Li, Jiafu Lin, Wenjuan Pan, Yiwen Chu, Balakrishnan Prithiviraj, Yidong Guo, Xinrong Wang*, Kelei Zhao*. Extracellular products-mediated interspecific interaction between Pseudomonas aeruginosa and Escherichia coli. Journal of Microbiology, 2021, 59: 29-40.
13.Kelei Zhao*, Jing Li, Yang Yuan, Jiafu Lin, Xinrong Wang, Yidong Guo, Yiwen Chu*. Nutrient factor-dependent performance of bacterial quorum sensing system during population evolution. Archives of Microbiology, 2020, 202(8): 2181-2188.
14.Kelei Zhao*, Yang Yuan, Jing Li, Wenjuan Pan, Chaochao Yan, Huiyao Fu, Jiafu Lin, Bisong Yue, Xinrong Wang, Xiaojun Gou, Yiwen Chu*, Yingshun Zhou*. Phenotypic and genetic characterization of Pseudomonas aeruginosa isolate COP2 from the lungs of COPD patients in China. Pathogens and Disease, 2019, 77: ftz038.
15.Kelei Zhao*, Jing Li, Ting Huang, Yang Yuan, Jiafu Lin, Bisong Yue, Xinrong Wang, Yiwen Chu*. Coexistence of microbial species in structured communities by forming a hawk-dove game like interactive relationship. Frontiers in Microbiology, 2019, 10: 807.
16.Kelei Zhao, Jinnan Ma, Xinrong Wang, Yidong Guo, Bisong Yue, Yiwen Chu*. Population divergence of Pseudomonas aeruginosa can lead to the coexistence with Escherichia coli in animal suppurative lesions. Veterinary Microbiology, 2019, 231: 169–176.
17.Kelei Zhao, Lianming Du, Jiafu Lin, Yang Yuan, Xiwei Wang, Bisong Yue, Xinrong Wang, Yidong Guo, Yiwen Chu*, Yingshun Zhou*. Pseudomonas aeruginosa quorum-sensing and type VI secretion system can direct interspecific coexistence during evolution. Frontiers in Microbiology, 2018, 9: 2287.
18.Xiangjin Yan, Jing Zeng, Xinyao Li, Zhikun Zhang, Ahmad Ud Din, Kelei Zhao*, Yingshun Zhou*. High incidence and characteristic of PRRSV and resistant bacterial Co-Infection in pig farms. Microbial Pathogenesis, 2020, 149: 104536.
19.Lingtong Tang, Jianglian Huang, Junping She, Kelei Zhao*, Yingshun Zhou*. Co-occurrence of the blaKPC-2 and Mcr-3.3 gene in Aeromonas caviae SCAc2001 isolated from patients with diarrheal disease. Infection and Drug Resistance, 2020, 13: 1527-1536.
20.Ting Huang*, Kelei Zhao, Xuhao Song, Tao Song, Xinrong Wang, Xiuyue Zhang, Bisong Yue, Yiwen Chu. Heterologous prime-boost immunization with DNA vaccine and modified recombinant proteins enhances immune response against Trueperella pyogenes in mice. Vaccines, 2022, 10: 839.
21.Tao Song, Xiaotao Wang, Minghao Wu, Kelei Zhao, Xinrong Wang, Yiwen Chu, Jiafu Lin*. Agarase cocktail from agar polysaccharide utilization loci converts homogenized gelidium amansii into neoagarooligosaccharides. Food Chemistry. 2020, 128685. DOI: 10.1016/j.foodchem.2020.128685.
22.Lianming Du, Qin Liu, Kelei Zhao, Jie Tang, Xiuyue Zhang, Bisong Yue*, Zhenxin Fan*. PSMD: An extensive database for pan-species microsatellite investigation and marker development. Molecular Ecology Resources 2020; 20:283–291.
23.Xin Liu, Jie Zhang, Yini Li, Qiuni Shen1 Wenting Jiang, Kelei Zhao, Yancheng He, Penggao Dai, Zhihao Nie, Xiyan Xu*, Yingshun Zhou*. Diversity and frequency of resistance and virulence genes in blaKPC and blaNDM co-producing Klebsiella pneumoniae strains from China. Infection and Drug Resistance, 2019:12 2819–2826.
24.Li Fu, Shanmei Wang, Zhikun Zhang, Xiangjing Yan, Xingyou Yang, Luhua Zhang, Ying Li, Guangxi Wang, Kelei Zhao*, Yingshun Zhou*. Co-carrying of KPC-2, NDM-5, CTX-M-3 and CTX-M-65 in three plasmids with serotype O89: H10 Escherichia coli strain belonging to the ST2 clone in China. Microbial Pathogenesis, 2019, 128: 1–6.
25.Yao Liu, Hong Zhang, Xinzhuo Zhang, Nan Jiang, Zhikun Zhang, Jinping Zhang, Baoli Zhu, Guangxi Wang, Kelei Zhao*, Yingshun Zhou*. Characterization of an NDM-19-producing Klebsiella pneumoniae strain harboring 2 resistance plasmids from China. Diagnostic Microbiology and Infectious Disease, 2019, 93: 355–361.
26.Ting Huang, Xuhao Song, Kelei Zhao, Jie Jing, Yongmei Shen, Xiuyue Zhang, Bisong Yue*. Quorum-sensing molecules N-Acyl homoserine lactones inhibit Trueperella pyogenes infection in mouse model. Veterinary Microbiology, 2018, 213: 89–94.
27.Ting Huang, Xuhao Song, Jie Jing, Kelei Zhao, Yongmei Shen, Xiuyue Zhang, Bisong Yue*. Chitosan-DNA nanoparticles enhanced the immunogenicity of multivalent DNA vaccination on mice against Trueperella pyogenes infection. Journal of Nanobiotechnology, 2018, 16: 8.
28.Xikun Zhou, Xuefeng Li, Yan Ye, Kelei Zhao, Yan Zhuang, Yi Li, Yuquan Wei, Min Wu*. MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to TLR/IRAK4 circuits. Nature Communications, 2014, 5: 3619.
29.Jie Tang, Mahfuzur R Shah, Dan Yao, Ying Jiang, Lianming Du, Kelei Zhao, Liheng Li, Meijin Li, Michal M Waleron, Malgorzata Waleron, Krzysztof Waleron, Maurycy Daroch. Polyphasic identification and genomic insights of Leptothermofonsia sichuanensis gen. sp. nov., a novel thermophilic cyanobacteria within Leptolyngbyaceae. Frontiers in Microbiology. 2022. 13: 765105.
30.Ting Huang*, Zheng Lv, Jiafu Lin, Kelei Zhao, Longfei Zhai, Xinrong Wang*, Yiwen Chu*. A potent antibiotic combination of linezolid and Polymycin B nonapeptide against Klebsiella pneumoniae infection in vitro and in vivo. Frontiers in Pharmacology. 2022. 13: 887941.

一、科研项目
1. 国家自然科学基金面上项目，2023/01-2026/12，主持；
2. 国家自然科学基金面上项目，2020/01-2023/12，主持；
3. 国家自然科学基金青年基金项目，2018/01-2020/12，主持；
4. 四川省杰出青年科技人才项目，2021/04-2024/04，主持；
5. 四川省科协青年人才托举工程项目，2018/01-2020/12，主持；
6. 成都大学高层次人才培育项目,2020/01-2025/01,主持；
7. 国家重大新药创制“十三五”科技重大专项子课题，2019/01-2020/12，参与
二、教学成果
获奖或荣誉称号：四川省“杰青”项目获得者围绕慢性呼吸道感染病原菌持久性定植机制，系统回答了病原菌如何拮抗宿主免疫系统、如何维持种群结构稳定、如何演化定植等科学问题，并基于筛选获得的新靶点进行了新型抗感染药物筛选，在Nature Microbiology, Cell Research, Briefings in Bioinformatics, BMC Biology, Environmental Microbiology, Applied and Environmental Microbiology, Frontiers in Microbiology等SCI期刊以及中国抗生素杂志、四川动物等中文核心期刊发表研究论文近50篇，其中第一/通讯作者34篇。先后主持国家自然科学基金青年基金项目1项(已结题)，面上项目2项，主研国家"十三五"重大新药创制子课题和四川省国合重点项目各1项，构建完成细菌群体效应抑制剂体外筛选平台、秀丽隐杆线虫-耐药菌感染高通量体内筛选平台，发现具有新作用机制的先导化合物50余个，申请中国发明专利5项，并入选四川省杰出青年科技人才(2021)、四川省科协托举青年人才(2018)和成都大学优秀青年人才(2019)。